Shape and size control of nanocrystals for biomedical applications (Tilley, Williams(D), Hendy)

We are part of a multidisciplinary team developing magnetic nanoparticles and quantum dots (QDs) for biomedical applications.  We propose to extend the liquid phase synthesis of QDs to new materials containing silicon and germanium.  Biomolecules, such as antibodies, will be attached to the QD surface with the aim of targeted delivery of drugs to disease sites. Magnetic nanoparticles are being developed can act as MRI contrast agents to improve cancer detection. Additionally, the question of how to control the growth of inorganic materials will be studied using synthetic polypeptides based on known biological analogues as novel modifiers of the nucleation and growth of nanocrystals. This work is in collaboration with Margaret Brimble (Maurice Wilkins Centre). Computer simulation and modeling of magnetic nanoparticles and QD properties is accompanying and guiding the synthetic work.