Biological nanomaterials such as self-assembled amyloid nanofibrils have the potential of making an enormous impact in future technologies because of the many advantages they provide as a protein nanomaterial, such as inexpensiveness, ease in production and high surface-to-volume ratios. Using biochemical and nanotechnological tools we have investigated their properties, showing additional benefits that make amyloid nanofibrils suitable for application as nanoscaffolds in biosensor systems.
From an analysis of their surface chemistry, we have developed several methods for the functionalization of amyloid nanofibrils with components such as quantum dots, metal nanoparticles, microbeads, conducting polymers and enzymes. An optical tweezers setup has been used to study their mechanical properties, and their electrical conductivity has been explored via a microelectrode-based approach. We have also investigated the effect of environmental conditions on amyloid nanofibril stability, focusing on temperature, pH, solvents, and presence of proteolytic enzymes. Finally, as an example and proof-of-concept, we show the use of amyloid nanofibrils as enzyme-nanoscaffolds in a biosensor platform for glucose detection.
Victoria University of Wellington, AMLT105
University of Otago, please use Scopia Desktop
University of Auckland, Dept of Physics, L6 Building 303, Room 303 610, 38 Princes St
Massey University, please use Scopia Desktop
Callaghan Innovation – Gracefield Campus, C-Block Meeting Room
University of Canterbury – Psychology 164
If you are unable to attend at one of the above locations the seminar can be viewed via Scopia Desktop