Bottom-Up Soft Engineering

In the spirit of traditional condensed matter physics, this Objective focuses on understanding how the macroscopic properties of soft materials emerge from the chemical composition of, and the interactions between, the molecular components. We study the organisation of proteins into higher order assemblies, building on our successful manufacture of protein nanotubes (fibrils) from readily available […]

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Interacting with the Animate

This objective concerns manipulations and measurements of single biological cells within controlled, specific micro and nano-environments. We have particular interest in examining the responses of biological cells to lithographically-defined surfaces and materials. The interactions of cells with bio-imprinted patterns, used as secondary culture platforms, can be explored – it is found that the cell morphology […]

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Transport in the Nanoworld

Understanding of nanofluidics has the potential to revolutionise the way in which particle sensing and analysis, and ultimately molecular biology, is done. We seek to manipulate transport of fluid and particles in and around micro- to nano-scale devices, individual pores and porous materials. We use elastomeric tunable nanopores to study a wide range of interesting […]

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Biology on-the-Fly

Ultra-sensitive spectroscopy – with special emphasis on single molecule Surface Enhanced Raman Scattering – will continue to grow from the recent successes in the application of the technique to reveal new aspects of the physics of isolated molecules (especially those of biological interest) on surfaces. Among recent developments, our group has demonstrated the possibility of […]

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Nanomaterials for Biological Applications

We use multidisciplinary approaches to develop magnetic nanoparticles, quantum dots (QDs) and silver nanoparticles for biomedical applications. Magnetic nanoparticles (including superparamagnetic nanoparticles) of well-defined shape are being developed with  Carla Meledandri. We are investigating their magnetic resonance properties in suspension, and their potential as MRI contrast agents to improve cancer detection. The question of how […]

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Bionano/Nanobio and Soft Matter

The disciplines of bionanotechnology, nanobiotechnology, and soft matter coalesce within this Research Theme. Biological systems can act as an inspiration, elegantly harnessing the special physics of the nano-world to perform ‘bottom-up’ processing with aplomb, generating smart, functional, viscoelastic matrices: from molecules to materials. Biology can also be the end-goal, with multidisciplinary teams driving towards applications […]

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