Professor John Evans
Phone: 03 364 4630
Dept of Obstetrics & Gynaecology
Christchurch School of Medicine and Health Sciences
University of Otago
PO Box 4345
Professor John Evans is employing BioImprinting, using cured polymer moulds of biological cells, in collaboration with A/P Maan Alkaisi, to study the link between mechanical forces imparted on cells by their neighbours and cancer development. He and his team had developed the method to improve imaging of pituitary cells by Atomic Force Microscopy. This approach enables novel clinical questions regarding drug responsiveness to be studied. Other studies of the interactions between nano- and micro-patterned surfaces enable the effect of the external chemico-physical environment on cell function to be delineated. Their collaboration allows them to ask entirely novel questions that are not accessible to other groups. The understanding derived from these studies is expected to impact on the development of artificial tissues and implants and the control of tumorigenicity of cells.
We are examining the effects of micro- and nano-environment on cell growth and the result of mechanical forces on the cells which produce signals that regulate genetic expression. The studies take the form of developing bioimprints of cultured cells and then placing cell types or cell lines on the substrates that are produced. The types of growths that eventuate will be determined (proliferation rate, location, clustering, apoptosis, protein expression, gene expression). Studies will be performed with cancer and pituitary cells. In the cancers we are also studying the effects of hypoxia on the production of angiogenic and other factors. These cells also allow us to grow 3-D mirotumours as cell clusters which provide a further approach to understanding the effects of structural forces.
Novel physical technologies will be used for studying biological systems, and exocytosis in cancer cells will be studied using the biochip and BioImprint technologies we have developed. Additionally, a new project has been established to investigate how cells interact with micro/nano patterns made of biocompatible materials. An investigation that will lead to bioactive/biocompatible coatings […]
John Evans, Principal Investigator in the MacDiarmid Institute is based at the Centre for Neuroendocrinology, University of Otago, Christchurch. Recently I visited four departments in Scotland and England, deciphered assorted accents and presented two seminars on our cell manipulation and imaging studies. The visits included discussions with members of groups who were considering […]
Writers of romantic songs may tell us that women are complicated beings, but if you want to hear how complicated women are, try talking to a reproductive endocrinologist. Associate Professor John Evans has spent the past three decades looking at the female reproductive system, from the early stirrings of ovulation through to determining the […]